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Laboratory of Neuropsychophysiology, Faculty of Psychology and Educational Sciences, University of Porto, Portugal
Department of Audiology, School of Allied Health Sciences, Polytechnic Institute of Porto, 4400-330 V.N. Gaia, Portugal
School of Criminology, Faculty of Law, University of Porto, Portugal
Department of Clinical Neurophysiology, University of Turku, Finland
David Tomé   

David Tomé, Laboratory of Neuropsychophysiology, Faculty of Psychology and Educational Sciences, University of Porto, Portugal, Tel.: +351 939591301; Fax: +351 222061001, e-mail: dts@estsp.ipp.pt
Publication date: 2020-04-17
J Hear Sci 2013;3(2):9–15
Temporal lobe epilepsy (TLE) is a neurological disorder that directly affects cortical areas responsible for auditory processing. The resulting abnormalities can be assessed using event-related potentials (ERP), which have high temporal resolution. However, little is known about TLE in terms of dysfunction of early sensory memory encoding or possible correlations between EEGs, linguistic deficits, and seizures. Mismatch negativity (MMN) is an ERP component – elicited by introducing a deviant stimulus while the subject is attending to a repetitive behavioural task – which reflects pre-attentive sensory memory function and reflects neuronal auditory discrimination and perceptional accuracy.

We propose an MMN protocol for future clinical application and research based on the hypothesis that children with TLE may have abnormal MMN for speech and non-speech stimuli. The MMN can be elicited with a passive auditory oddball paradigm, and the abnormalities might be associated with the location and frequency of epileptic seizures.

The suggested protocol might contribute to a better understanding of the neuropsychophysiological basis of MMN. We suggest that in TLE central sound representation may be decreased for speech and non-speech stimuli.

MMN arises from a difference to speech and non-speech stimuli across electrode sites. TLE in childhood might be a good model for studying topographic and functional auditory processing and its neurodevelopment, pointing to MMN as a possible clinical tool for prognosis, evaluation, follow-up, and rehabilitation for TLE.

Helmstaedter C, Kurthen M. Memory and epilepsy – characteristics, course, and influence of drugs and surgery. Curr Opin Neurol, 2001; 14: 211–16.
Mantoan M, da Silva T, Alonso N, Noffs M, Marques C, Rios L et al. Neuropsychological assessment and quality of life in patients with refractory temporal lobe epilepsy related to hippocampal sclerosis. J Epilepsy Clin Neurophysiol, 2006; 12(4): 201–6.
Mintzer S, Cendes F, Soss J, Andermann F, Engel Jr J, Dubeau F et al. Unilateral hippocampal sclerosis with contralateral temporal scalp ictal onset. Epilepsia, 2004; 45(7): 792–802.
Ballaban-Gil K. Language disorders and epilepsy. In: Pedley TA, Meldrum BS. (eds.). Recent Advances in Epilepsy.Churchill Livingstone, Edinburgh, 1995; 205–20.
Loring DW, Hermann BP, Lee GP, Drane DL, Meador KJ. The memory assessment scales and lateralized temporal lobe epilepsy. J Clin Psychol, 2000; 56: 563–70.
Hendriks MP, Aldenkamp AP, Alpherts WC, Ellis J, Vermeulen J, van der Vlugt H. Relationships between epilepsy-related factors and memory impairment. Acta Neurol Scand, 2004; 110: 291–300.
Butler CR, Zeman AZ. Recent insights into the impairment of memory in epilepsy: transient epileptic amnesia, accelerated long-term forgetting and remote memory impairment. Brain, 2008; 131(Pt.9): 2243–63.
McCagh J, Fisk JE, Baker GA. Epilepsy, psychosocial and cognitive functioning. Epilepsy Res, 2009; 86: 1–14.
Tomé D, Jesus E, Esteves M. Auditory middle latency response in epilepsy. Sinapse, 2011; 11: 5–11.
Näätänen R, Gaillard AWK, Mäntysalo S. Early selective-attention effect on evoked potential reinterpreted. Acta Psychol, 1978; 42: 313–29.
Näätänen R, Paavilainen P, Alho K, Reinikainen K, Sams M. The mismatch negativity to intensity changes in an auditory stimulus sequence. Electroencephalogr Clin Neurophysiol Suppl, 1987; 40: 125–31.
Näätänen R. The perception of speech sounds by the human brain as reflected by the mismatch negativity (MMN) and its magnetic equivalent (MMNm). Psychophysiology, 2001; 38: 1–21.
Näätänen R, Kujala T, Escera C, Baldeweg T, Kreegipuu K, Carlson S et al. The mismatch negativity (MMN) – a unique window to disturbed central auditory processing in ageing and different clinical conditions. Clin Neurophysiol, 2012; 123(3): 424–58.
Näätänen R: Mismatch negativity: clinical research and possible applications. Int J Psychophysiol, 2003; 48: 179–88.
Näätänen R, Paavilainen P, Rinne T, Alho K. The mismatch negativity (MMN) in basic research of central auditory processing: a review. Clin Neurophysiol, 2007; 118: 2544–90.
Liasis A, Towell A, Boyd S. Intracranial auditory detection and discrimination potentials as substrates of echoic memory in children. Cognit Brain Res, 1999; 7: 503–6.
Giard MH, Perrin F, Pernier J, Bouchet P. Brain generators implicated in processing of auditory stimulus deviance: a topographic event-related potential study. Psychophysiology, 1990; 27: 627–40.
Escera C, Corral MJ: Role of mismatch negativity and novelty-P3 in involuntary auditory attention. J Psychophysiol, 2007; 21: 251–64.
Boatman DF, Trescher WH, Smith C, Ewen J, Los J, Wied HM et al. Cortical auditory dysfunction in benign rolandic epilepsy. Epilepsia, 2008; 49: 1018–26.
Miyajima M, Ohta K, Hara K, Iino H, Maehara T, Hara M et al. Abnormal mismatch negativity for pure-tone sounds in temporal lobe epilepsy. Epilepsy Res, 2011; 94: 149–57.
Honbolygó F, Csépe V, Fekésházy A, Emri M, Márián T, Sárközy G et al. Covering evidences on language impairment in Landau-Kleffner Syndrome revealed by behavioural and brain activity measures: a case study. Clin Neurophysiol, 2006; 117: 295–305.
Commission on Classification and Terminology of the International League Against Epilepsy: Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia, 1989; 30: 389–99.
Bureau International d’Audiophonologie (BIAP): Recommendation BIAP no. 02/1 bis. Classification audiométrique des deficiencies auditives. 2005; http://www.biap.org/recom02-1.... [in French].
Martin B, Sigal A, Kurtzberg D, Stapells D. The effects of decreased audibility produced by high-pass noise masking on cortical event-related potentials to speech sounds /ba/ and /da/. J Acoust Soc Am, 1997; 101: 1585–99.
Martin B, Kurtzberg D, Stapells D. The effects of decreased audibility produced by high-pass noise masking on N1 and the mismatch negativity to speech sounds /ba/ and /da/. J Speech, Lang Hear Res, 1999; 42: 271–86.
Hari R, Hämäläinen M, Ilmoniemi R, Kaukoranta E, Reinikainen K, Salminen J et al. Responses of the primary auditory cortex to pitch changes in a sequence of tone pips: neuromagnetic recordings in man. Neurosci Lett, 1984; 50: 127–32.
Escera C, Corral MJ, Yago E. An electrophysiological and behavioral investigation of involuntary attention towards auditory frequency, duration and intensity changes. Cogn Brain Res, 2002; 14: 325–32.
Kujala T, Näätänen R. The mismatch negativity in evaluating central auditory dysfunctions in dyslexia. Neurosci Biobehav Rev, 2001; 25: 535–43.
Liasis A, Bamiou DE, Boyd S, Towell A. Evidence for a neurophysiologic auditory deficit in children with benign epilepsy with centro-temporal spikes. J Neural Trans, 2006; 113: 939–49.
Marler JA, Chamolin CA, Gillam RB. Auditory memory for backward masking signals in children with language impairment. Psychophysiology, 2002; 39: 767–80.
Groenen P, Snik A, van der Broek P. On the clinical relevance of mismatch negativity: results from subjects with normal hearing and cochlear implant users. Audiol Neuro-Otology, 1996; 1: 112–14.
Wable J, van der Abbeele T, Gallégo S, Frachet B. Mismatch negativity: a tool for the assessment of stimuli discrimination in cochlear implant subjects. Clin Neurophysiol, 2000; 111: 743–51.
Korpilahti P, Lang HA. Auditory ERP components and mismatch negativity in dysphasic children. Electroencephalogr Clin Neurophysiol, 1994; 91(4): 256–64.
Uwer R, Ronald R, von Suchodoletz W. Automatic processing of tones and speech stimuli in children with specific language impairment. Dev Med Child Neurol, 2002; 44: 527–32.
Metz-Lutz M-N, Philippini M. Neuropsychological findings in rolandic epilepsy and Landau–Kleffner syndrome. Epilepsia, 2006; 47: S71–75.
Hough MS, Downs CR, Cranford J, Givens G. Measures of auditory processing in aphasia: behavioural and electrophysiological analysis. Aphasiology, 2003; 17(2): 159–72.
Ilvonen T, Kujala T, Kozou H, Kiesiläinen A, Salonen O, Alku P et al. The processing of speech and non-speech sounds in aphasic patients as reflected by the mismatch negativity (MMN). Neurosci Lett, 2004; 366: 235–40.
Särkämö T, Pihko E, Laitinen S, Forsblom A, Soinila S, Mikkonen M et al. Music and speech listening enhance the recovery of early sensory processing after stroke. J Cognitive Neurosci, 2010a; 22: 2716–27.
Särkämö T, Tervaniemi M, Laitinen S, Forsblom A, Soinila S, Mikkonen M et al. Music listening enhances cognitive recovery and mood after middle cerebral artery stroke. Brain, 2008; 131: 866–76.
Robin D, Tranel D, Damasio H. Auditory perception of temporal and spectral events in patients with focal left and right cerebral lesions. Brain Lang, 1990; 39: 539–55.
Gene-Cos N, Pottinger R, Barrett G, Trimble MR, Ring HA. A comparative study of mismatch negativity (MMN) in epilepsy and non-epileptic seizures. Epileptic Disord, 2005; 7: 363–72.
Rosburg T, Trautner P, Dietl T, Korzyukov OA, Boutros NN, Schaller C et al. Subdural recordings of the mismatch negativity (MMN) in patients with focal epilepsy. Brain, 2005; 128: 819–28.
Piazzini A, Turner K, Chifari R, Morabito A, Canger R,Canevini MP. Attention and psychomotor speed decline in patients with temporal lobe epilepsy: a longitudinal study. Epilepsy Res, 2006; 72: 89–96.
Lagae L. Cognitive side effects of anti-epileptic drugs. The relevance in childhood epilepsy. Seizure, 2006; 5: 235–41.
Näätänen R. The role of attention in auditory information process as revealed by event-related potentials and other brain measures of cognitive function. Behav Brain Sci, 1990; 13: 201–88.
Winkler I. Interpreting the mismatch negativity. J Psychophysiol, 2007; 21(3–4): 147–63.
May P, Tiitinen H. Mismatch negativity (MMN), the devianceelicited auditory deflection, explained. Psychophysiology, 2010; 47: 66–122.
Näätänen R, Winkler I. The concept of auditory stimulus representation in cognitive neuroscience. Psychol Bull, 1999; 125: 826–59.
Jääskeläinen IP, Ahveninen J, Bonmassar G, Dale AM, Ilmoniemi RJ, Levänen S et al. Human posterior auditory cortex gates novel sounds to consciousness. Proc Natl Acad Sci USA, 2004; 101: 6809–14.
Hara K, Ohta K, Miyajima M, Hara M, Iino H, Matsuda A et al. Mismatch negativity for speech sounds in temporal lobe epilepsy. Epilepsy Behav, 2012; 23: 335–41.
Shestakova A, Brattico E, Huotilainen M, Galunov V, Soloviev A, Sams M et al. Abstract phoneme representations in the left temporal cortex: magnetic mismatch negativity study. Neuroreport, 2002; 13: 1813–16.
Shestakova A, Huotilainen M, Ceponiene R, Cheour M. Eventrelated potentials associated with second language learning in children. Clin Neurophysiol, 2003; 114: 1507–12.
Ilvonen T-M, Kujala T, Kiesiläinen A, Salonen O, Kozou H, Pekkonen E et al. Auditory discrimination after left hemisphere stroke: an MMN follow-up study. Stroke, 2003; 34: 1746–53.
Ilvonen T-M, Kujala T, Tervaniemi M, Salonen O, Näätänen R, Pekkonen E. The processing of sound duration after left hemisphere stroke: event-related potential and behavioral evidence. Psychophysiology, 2001; 38: 622–28.
Pettigrew C, Murdoch B, Kei J, Ponton C, Alku P, Chenery H. The mismatch negativity (MMN) response to complex tones and spoken words in individuals with aphasia. Aphasiology, 2005; 19(2): 131–63.
Näätänen R, Alho K. Mismatch negativity: the measure for central sound representation accuracy. Audiol Neuro-Otol, 1997; 2: 341–53.