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ORIGINAL ARTICLE
EFFECT OF FETAL HEMOGLOBIN LEVEL ON AUDITORY DISCRIMINATION IN INDIVIDUALS WITH SICKLE CELL ANEMIA
1
Department of ENT and HNS, All India Institute of Medical Sciences, Raipur, India
2
Department of Audiology, All India Institute of Speech and Hearing, Mysuru, India
These authors had equal contribution to this work
A - Research concept and design; B - Collection and/or assembly of data; C - Data analysis and interpretation; D - Writing the article; E - Critical revision of the article; F - Final approval of article;
Submission date: 2024-02-24
Final revision date: 2025-01-14
Acceptance date: 2025-02-26
Online publication date: 2025-03-28
Publication date: 2025-03-28
Corresponding author
Preeti Sahu
Department of ENT and HNS, All India Institute of Medical Sciences, Tatibandh, 492099, Raipur, India
Department of ENT and HNS, All India Institute of Medical Sciences, Tatibandh, 492099, Raipur, India
J Hear Sci 2024;14(4):35-41
KEYWORDS
fetal hemoglobin (HbF)difference limen for frequencydifference limen for intensityduration discrimination testspeech perception in noise
TOPICS
ABSTRACT
Introduction:
Sickle cell anemia (SCA) is an inherited disorder characterized by hemolysis and vaso-occlusive crises. Hydroxyurea (HDU) is the primary drug available for SCA which increases the concentration of fetal hemoglobin (HbF) and has shown clinically beneficial effects ranging from 15 to 20% on sickle cells. The present study aimed to investigate the impact of HbF level on auditory discrimination ability and speech perception in noise in normal hearing individuals with SCA under HDU treatment.
Material and methods:
A between-subject design was used for group comparison. Non-random purposive sampling was used to select participants from a local Hindi-speaking community. A total of 66 normal-hearing adults diagnosed with SCA and under medication with HDU in the age range of 18–40 years were divided into three groups based on HbF%. Auditory discrimination for frequency (DLF), intensity (DLI), and duration (DDT) were evaluated at 500 Hz and 4000 Hz along with SPIN at 0 dB SNR using the MLP toolbox in Matlab.
Results:
Comparing the three HbF groups, Kruskal–Wallis tests revealed no significant difference in auditory discrimination based on either DLF, DLI, DDT, or SPIN scores.
Conclusions:
The present study indicated no impact on the auditory system of raised HbF level in SCA individuals. The findings suggest that in such individuals not every system in the body is affected equally by raised HbF levels.
Sickle cell anemia (SCA) is an inherited disorder characterized by hemolysis and vaso-occlusive crises. Hydroxyurea (HDU) is the primary drug available for SCA which increases the concentration of fetal hemoglobin (HbF) and has shown clinically beneficial effects ranging from 15 to 20% on sickle cells. The present study aimed to investigate the impact of HbF level on auditory discrimination ability and speech perception in noise in normal hearing individuals with SCA under HDU treatment.
Material and methods:
A between-subject design was used for group comparison. Non-random purposive sampling was used to select participants from a local Hindi-speaking community. A total of 66 normal-hearing adults diagnosed with SCA and under medication with HDU in the age range of 18–40 years were divided into three groups based on HbF%. Auditory discrimination for frequency (DLF), intensity (DLI), and duration (DDT) were evaluated at 500 Hz and 4000 Hz along with SPIN at 0 dB SNR using the MLP toolbox in Matlab.
Results:
Comparing the three HbF groups, Kruskal–Wallis tests revealed no significant difference in auditory discrimination based on either DLF, DLI, DDT, or SPIN scores.
Conclusions:
The present study indicated no impact on the auditory system of raised HbF level in SCA individuals. The findings suggest that in such individuals not every system in the body is affected equally by raised HbF levels.
FUNDING
This research and article did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
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