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REVIEW PAPER
CLINICAL ROLE OF miRNA BIOMARKERS IN LARYNGEAL SQUAMOUS CELL CARCINOMA (LSCC): LITERATURE REVIEW
1
Student Scientific Club at the Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, Poland
A - Research concept and design; B - Collection and/or assembly of data; C - Data analysis and interpretation; D - Writing the article; E - Critical revision of the article; F - Final approval of article;
Submission date: 2023-02-23
Final revision date: 2023-07-19
Acceptance date: 2023-07-21
Online publication date: 2023-12-22
Publication date: 2023-12-22
Corresponding author
Barbara Rusinowska
Student Scientific Club at the Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, Radziwiłłowska 11, 20-080, Lublin, Poland
Student Scientific Club at the Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, Radziwiłłowska 11, 20-080, Lublin, Poland
J Hear Sci 2023;13(4):9-16
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Malignant transformations may result from gene dysregulation caused by genetic and epigenetic modifications. The use of miRNAs to treat cancer depends on the downregulation or upregulation of the miRNAs responsible for carcinogenesis (proliferation, angiogenesis, invasion, metastasis), providing the opportunity to suppress tumors. The purpose of this review is to list miRNAs identified so far as biomarkers in laryngeal squamous cell carcinoma (LSCC). This listing may help in predicting the evolution of miRNAs and developing anti-miRNAs and miRNA-mimics as anti-cancer therapies.
Material and methods:
Relevant publications from 2008 to 2022 were retrieved from the PubMed and Google Scholar databases, using the key words miRNA (PubMed – 149,294 results; Google Scholar – 205,000 results), laryngeal squamous cell carcinoma (PubMed – 33,191 results; Google Scholar – 17,900 results), laryngeal squamous cell carcinoma biomarkers (PubMed – 6249 results; Google Scholar – 18,000 results), laryngeal squamous cell carcinoma miRNA (PubMed – 1338 results; Google Scholar – 17,500 results). Eventually 51 papers were selected for review.
Results:
We identified 51 studies which have detected miRNA-based biomarkers for LSCC, and they are broadly reviewed here.
Conclusions:
The identified laryngeal squamous cell-specific miRNA biomarkers appear to be promising for the detection, predicted course, and treatment of LSCC.
Malignant transformations may result from gene dysregulation caused by genetic and epigenetic modifications. The use of miRNAs to treat cancer depends on the downregulation or upregulation of the miRNAs responsible for carcinogenesis (proliferation, angiogenesis, invasion, metastasis), providing the opportunity to suppress tumors. The purpose of this review is to list miRNAs identified so far as biomarkers in laryngeal squamous cell carcinoma (LSCC). This listing may help in predicting the evolution of miRNAs and developing anti-miRNAs and miRNA-mimics as anti-cancer therapies.
Material and methods:
Relevant publications from 2008 to 2022 were retrieved from the PubMed and Google Scholar databases, using the key words miRNA (PubMed – 149,294 results; Google Scholar – 205,000 results), laryngeal squamous cell carcinoma (PubMed – 33,191 results; Google Scholar – 17,900 results), laryngeal squamous cell carcinoma biomarkers (PubMed – 6249 results; Google Scholar – 18,000 results), laryngeal squamous cell carcinoma miRNA (PubMed – 1338 results; Google Scholar – 17,500 results). Eventually 51 papers were selected for review.
Results:
We identified 51 studies which have detected miRNA-based biomarkers for LSCC, and they are broadly reviewed here.
Conclusions:
The identified laryngeal squamous cell-specific miRNA biomarkers appear to be promising for the detection, predicted course, and treatment of LSCC.
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