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“INFLAMMAGING” AND ITS MANAGEMENT IN PRESBYCUSIS
1
Institute of Sound and Vibration Research, Faculty of Engineering and the Environment, University of
Southampton, U.K.
Publication date: 2012-12-31
Corresponding author
Carl Verschuur
Carl Verschuur, Institute of Sound and Vibration Research, Faculty of Engineering and the Environment, University of Southampton, U.K., e-mail: cav@isvr.soton.ac.uk
Carl Verschuur, Institute of Sound and Vibration Research, Faculty of Engineering and the Environment, University of Southampton, U.K., e-mail: cav@isvr.soton.ac.uk
J Hear Sci 2012;2(4):46–48
ABSTRACT
Background:
From human studies there is little published evidence on the biological basis for presbycusis. We report a previously published study which tested the hypothesis that chronic inflammation in the elderly, known as “inflammaging” is a causal factor for presbycusis.
Material and Methods:
Analysis of biological and audiological data from a large population cohort showed an independent association between a range of inflammatory markers and mean hearing level.
Discussion:
Our findings suggest that further investigation into the role of inflammation in causing presbycusis is warranted. We also discuss wider research plans, and argue for a greater understanding of the inter-relationship of systemic and cochlear inflammation and the role of inflammatory processes in causing a range of types of hearing loss.
From human studies there is little published evidence on the biological basis for presbycusis. We report a previously published study which tested the hypothesis that chronic inflammation in the elderly, known as “inflammaging” is a causal factor for presbycusis.
Material and Methods:
Analysis of biological and audiological data from a large population cohort showed an independent association between a range of inflammatory markers and mean hearing level.
Discussion:
Our findings suggest that further investigation into the role of inflammation in causing presbycusis is warranted. We also discuss wider research plans, and argue for a greater understanding of the inter-relationship of systemic and cochlear inflammation and the role of inflammatory processes in causing a range of types of hearing loss.
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