ORIGINAL ARTICLE
LEVELS OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 DIFFER FROM THE NORM IN PATIENTS WITH SUDDEN SENSORINEURAL HEARING LOSS
 
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1
Department of Otorhinolaryngology, University of Regensburg, Germany
2
Department of Otorhinolaryngology, University of Zurich, Switzerland
CORRESPONDING AUTHOR
Frank Haubner   

Frank Haubner, Department of Otorhinolaryngology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany, Phone: +49-941-9449515, Fax: +49-941-9449415, e-mail: frank.haubner@klinik.uni-regensburg.de
Publication date: 2020-04-20
 
J Hear Sci 2012;2(1):36–40
 
ABSTRACT
Background:
The aim of this study was to evaluate the role of cytokines and soluble adhesion molecules in patients with sudden sensorineural hearing loss (SSNHL) with respect to their pure-tone audiometry values.

Material and Methods:
This study analyses blood samples of 51 patients with SSNHL. Serum levels of ICAM-1, VCAM-1, E-selectin, IL-6, IL-8, and MCP-1 were evaluated by ELISA. Pure-tone audiometry data were compared before and after a systemic steroid treatment regimen. The subjects with SSNHL were compared to a control group of 44 patients with normal hearing and matching age and gender. The data complete our previous data collection.

Results:
There is trend toward suppressed levels of MCP-1 in sera of SSNHL patients. There were no statistically significant differences concerning ICAM-1, VCAM-1, E-selectin, IL-6, IL-8, and MCP-1 between SSNHL patients and controls. Puretone audiometry of the SSNHL group showed a significant improvement in hearing after systemic steroid therapy and a median follow-up of 4 months.

Conclusions:
Further prospective studies are necessary to prove the role of MCP-1 and other cytokines in SSNHL in order to develop adequate treatment regimens.

 
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