ORIGINAL ARTICLE
LEVELS OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 DIFFER FROM THE NORM IN PATIENTS WITH SUDDEN SENSORINEURAL HEARING LOSS
 
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1
Department of Otorhinolaryngology, University of Regensburg, Germany
 
2
Department of Otorhinolaryngology, University of Zurich, Switzerland
 
 
Publication date: 2012-03-31
 
 
Corresponding author
Frank Haubner   

Frank Haubner, Department of Otorhinolaryngology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany, Phone: +49-941-9449515, Fax: +49-941-9449415, e-mail: frank.haubner@klinik.uni-regensburg.de
 
 
J Hear Sci 2012;2(1):36-40
 
ABSTRACT
Background:
The aim of this study was to evaluate the role of cytokines and soluble adhesion molecules in patients with sudden sensorineural hearing loss (SSNHL) with respect to their pure-tone audiometry values.

Material and Methods:
This study analyses blood samples of 51 patients with SSNHL. Serum levels of ICAM-1, VCAM-1, E-selectin, IL-6, IL-8, and MCP-1 were evaluated by ELISA. Pure-tone audiometry data were compared before and after a systemic steroid treatment regimen. The subjects with SSNHL were compared to a control group of 44 patients with normal hearing and matching age and gender. The data complete our previous data collection.

Results:
There is trend toward suppressed levels of MCP-1 in sera of SSNHL patients. There were no statistically significant differences concerning ICAM-1, VCAM-1, E-selectin, IL-6, IL-8, and MCP-1 between SSNHL patients and controls. Puretone audiometry of the SSNHL group showed a significant improvement in hearing after systemic steroid therapy and a median follow-up of 4 months.

Conclusions:
Further prospective studies are necessary to prove the role of MCP-1 and other cytokines in SSNHL in order to develop adequate treatment regimens.

 
REFERENCES (18)
1.
Ohinata Y, Makimoto K, Kawakami M et al: Blood viscosity and plasma viscosity in patients with sudden deafness. Acta Otolaryngol, 1994, 114(6): 601–7.
 
2.
Nagaoka J, Anjos MF, Takata TT et al: Idiopathic sudden sensorineural hearing loss: evolution in the presence of hypertension, diabetes mellitus and dyslipidemias. Braz J Otorhinolaryngol, 76(3): 363–69.
 
3.
Canis M, Heigl F, Hettich R et al: [Fibrinogen/LDL apheresis for treatment of sudden hearing loss: An observational study on 152 patients.]. Hno, 2008, 56(9): 961–66.
 
4.
Adams JC: Clinical implications of inflammatory cytokines in the cochlea: a technical note. Otol Neurotol, 2002, 23(3): 316–22.
 
5.
Quaranta N, Ramunni A, Brescia P et al: Soluble intercellular adhesion molecule 1 and soluble vascular cell adhesion molecule 1 in sudden hearing loss. Otol Neurotol, 2008, 29(4): 470–74.
 
6.
Yadav A, Saini V, Arora S: MCP-1: chemoattractant with a role beyond immunity: a review. Clin Chim Acta, 2010, 411(21–22): 1570–79.
 
7.
Melgarejo E, Medina MA, Sanchez-Jimenez F, Urdiales JL: Monocyte chemoattractant protein-1: a key mediator in inflammatory processes. Int J Biochem Cell Biol, 2009, 41(5): 998–1001.
 
8.
Haubner F, Martin L, Steffens T et al: The role of soluble adhesion molecules and cytokines in sudden sensorineural hearing loss. Otolaryngol Head Neck Surg, 2011; 144(4): 575–80.
 
9.
Takebayashi K, Suetsugu M, Matsumoto S et al: Effects of rosuvastatin and colestimide on metabolic parameters and urinary monocyte chemoattractant protein-1 in type 2 diabetic patients with hyperlipidemia. South Med J, 2009, 102(4): 361–68.
 
10.
Lukacs NW, Strieter RM, Elner V et al: Production of chemokines, interleukin-8 and monocyte chemoattractant protein-1, during monocyte: endothelial cell interactions. Blood, 1995; 86(7): 2767–73.
 
11.
Moon SK, Woo JI, Lee HY et al: Toll-like receptor 2-dependent NF-kappaB activation is involved in nontypeable Haemophilus influenzae-induced monocyte chemotactic protein 1 up-regulation in the spiral ligament fibrocytes of the inner ear. Infect Immun, 2007; 75(7): 3361–72.
 
12.
Moon SK, Park R, Lee HY et al: Spiral ligament fibrocytes release chemokines in response to otitis media pathogens. Acta Otolaryngol, 2006; 126(6): 564–69.
 
13.
Ogino K, Kato M, Furuse Y et al: Addition of losartan to angiotensin-converting enzyme inhibitors improves insulin resistance in patients with chronic heart failure treated without beta-blockers. Circ J, 2010; 74(11): 2346–52.
 
14.
Tretjakovs P, Jurka A, Bormane I et al: Relation of inflammatory chemokines to insulin resistance and hypoadiponectinemia in coronary artery disease patients. Eur J Intern Med, 2009; 20(7): 712–17.
 
15.
Bianchi LM, Daruwalla Z, Roth TM et al: Immortalized mouse inner ear cell lines demonstrate a role for chemokines in promoting the growth of developing statoacoustic ganglion neurons. J Assoc Res Otolaryngol, 2005; 6(4): 355–67.
 
16.
Schreiber BE, Agrup C, Haskard DO, Luxon LM: Sudden sensorineural hearing loss. Lancet, 2010, 375(9721): 1203–11.
 
17.
Gordin A, Goldenberg D, Golz A et al: Magnesium: a new therapy for idiopathic sudden sensorineural hearing loss. Otol Neurotol, 2002; 23(4): 447–51.
 
18.
Chau JK, Lin JR, Atashband S et al: Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. Laryngoscope, 2010, 120(5): 1011–21.
 
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