CASE STUDY
BILATERAL OTITIS MEDIA AND UNILATERAL SENSORINEURAL HEARING LOSS AS THE FIRST SIGNS OF WEGENER’S GRANULOMATOSIS
 
More details
Hide details
1
ENT Clinic, Attikon Hospital, University of Athens, Athens, Greece
CORRESPONDING AUTHOR
George S. Korres   

Dr George Korres, 10-12 Dorilaiou St., N. Erythraia, 14671, Athens, Greece, Phone: +30 6945 997916, e-mail: gfkorres@gmail.com
Publication date: 2020-04-17
 
J Hear Sci 2013;3(1):47–50
KEYWORDS
ABSTRACT
Background:
Wegener’s granulomatosis (WG) is a rare disease characterised by blood vessel inflammation. Due to its endorgan damage it is life threatening, primarily affecting the upper and lower respiratory tract (nose, sinuses, trachea, lungs) and the kidneys.

Materials, Methods, Results:
In this paper we describe the case of a 46-year-old woman who within one year developed bilateral otitis media and unilateral sensorineural hearing loss as the first clinical manifestations of Wegener’s granulomatosis.

Conclusions:
Even though bilateral otitis media is not a rare condition, in some cases it can be associated with a systemic disease. Suspicion of such a diagnosis should be reinforced when sensorineural hearing loss is present and the history of chronic otitis media is short. In the absence of other typical findings, the role of the otorhinolaryngologist is very important and any case with such symptoms should be thoroughly investigated.

 
REFERENCES (15)
1.
Engel F, Blatz R, Kellner J, Palmer M, Weller U, Bhadki S. Breakdown of the round window membrane permeability barrier evoked by streptolysin O: possible etiologic role in development of sensorineural hearing loss in acute otitis media. Infect Immun, 1995; 63(4): 1305–10.
 
2.
Takagi D, Nakamaru Y, Magachi S, Faruta Y, Fukuda S. Otologic manifestations of Wegener’s granulomatosis. Laryngoscope, 2002; 112: 1684–90.
 
3.
D’Cruz DP, Baguley E, Asherson RA, Hughes GR. Ear, nose,throat symptoms in subacute Wegener’s granulomatosis. BMJ, 1989; 299: 419–22.
 
4.
McCaffrey TV, McDonald TJ, Facer GW, DeRemee RA. Otologic manifestations of Wegener’s granulomatosis. Otolaryngol Head Neck Surg, 1980; 88: 586–93.
 
5.
Luqmani R, Jubb R, Emery P, Reid A, Adu D. Inner ear deafness in Wegener’s granulomatosis. J Rheumatol, 1991; 18: 766–68.
 
6.
Van der Woude FJ, Rasmussen N, Lobatto S et al. Autoantibodies against neutrophils and monocytes: Tool for diagnosis and marker of disease activity in Wegener’s granulomatosis. Lancet, 1985; 1: 425–29.
 
7.
Ohlsson K, Olsson I. The neutral proteases of human granulocytes.Isolation and partial characterization of granulocyte elastases. Eur J Biochem, 1974; 42: 519–27.
 
8.
Rao NV, Wehner NG, Marshall BC, Gray WR, Gray BH, Hoidal JR. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. J Biol Chem, 1991; 266: 9540–48.
 
9.
Dewald B, Rindler-Ludwig R, Bretz U, Baggiolini M. Subcellular localization and heterogeneity of neutral proteases in neutrophilic polymorphonuclear leukocytes. J Exp Med, 1975; 141: 709–23.
 
10.
Gabay JE, Heiple JM, Cohn ZA, Nathan CF. Subcellular location and properties of bactericidal factors from human neutrophils. J Exp Med, 1976; 164: 1407–21.
 
11.
Dengler R, Munstermann U, al Batran S, Hausner I, Faderl S, Nerl C, Emmerich B: Immunocytochemical and flow cytometric detection of proteinase 3 (myeloblastin) in normal and leukaemic myeloid cells. Br J Haematol, 1985; 89: 250–57.
 
12.
Pinède L, Ninet J, Duhaut P, Coppère B, Demolombe-Rague S, Girard-Madoux MH, Pasquier J. [Wegener granulomatosis. Anatomoclinical study. Review of the literature]. Ann Med Interne (Paris), 1995; 146(5): 339–64. [in French].
 
13.
Kloeck I, Crols R, De Belder T, Vandist V, Schmelzer B. Wegener’s granulomatosis presenting as otomastoiditis. A case report. B-ENT, 2006; 2(1): 7–12.
 
14.
Wierzbicka M, Puszczewicz M, Bartochowska A, Szyfter W. The otologic manifestation of Wegener’s granulomatosis – review of contemporary achievements in diagnostics and treatment. Otolaryngol Pol, 2012; 66(4): 254–58.
 
15.
Wierzbicka M, Szyfter W, Puszczewicz M, Borucki L, Bartochowska A. Otologic symptoms as initial manifestation of wegener granulomatosis: diagnostic dilemma. Otol Neurotol, 2011; 32(6): 996–1000.
 
eISSN:2084-3127
ISSN:2083-389X